It is the most important endpoint and the one that is least subject to investigator bias. 这是最重要的终点，以及为最小程度受制于研究者偏倚的一个。
Limitations of the study include lack of generalizability to physicians not involved in a research network, and possible response bias or other unmeasured bias. 研究的不足主要在于缺乏对调查网络外的医师的扩大调查，以及反馈偏倚或其它未预料到的偏倚。
